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研究成果概要


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VMAT2 safeguards beta-cells against dopamine cytotoxicity under high-fat diet induced stress. Sakano D, Uefune F, Tokuma H, Sonoda Y, Matsuura K, Takeda N, Nakagata N, Kume K, Shiraki N, Kume S. Diabetes (Eng ver) 69, 1-15, 2020.online ahead of print. Aug 21, 2020.https://dx.doi.org/10.2337/db20-0207

Insulin2 Q104del (Kuma) Mutant Mice Develop Diabetes with Dominant Inheritance. Daisuke Sakano, Airi Inoue, Takayuki Enomoto, Mai Imasak, Seiji Okada, Mutsumi Yokota, Masato Koik, Kimi Araki K, Shoen Kume. Sci Reports (Eng ver) 2020. doi: 10.1038/s41598-020-68987-z.

Dopamine D2 receptor-mediated regulation of beta cell mass.
Daisuke Sakano, Sungik Choi, Masateru Kataoka, Nobuaki Shiraki, Motonari Uesugi, Kazuhiko Kume, Shoen Kume.
Stem Cell Report 7, 95-109, 2016.

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[+] Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells.
Nobuaki Shiraki, Yasuko Shiraki, Tomonori Tsuyama, Fumiaki Obata, Masayuki Miura, Genta Nagae, Hiroyuki Aburatani, Kazuhiko Kume, Fumio Endo, Shoen Kume. Cell Metabolism19, 780-794, 2014

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[+] Guided differentiation of ES cells into Pdx1-expressing regional specific definitive endoderm.

Nobuaki Shiraki, Tetsu Yoshida, Kimi Araki, Akihiro Umezawa, Yuichiro Higuchi, Hideo Goto, Kazuhiko Kume, Shoen Kume, S.
Stem Cells 26, 874-885, 2008.

ホーム 研究プロジェクト 研究成果概要 発表論文 メンバー紹介 アクセス・募集

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